2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-RS16310
    S100a1 Rat Pre-designed siRNA Set A

    S100a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for S100a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S100a1 Rat Pre-designed siRNA Set A
  • HY-W009512
    CVT-2738 5294-61-1 99.81%
    CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities.
    CVT-2738
  • HY-W099479
    Insect repellent M 3535 52304-36-6 98.44%
    Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway.
    Insect repellent M 3535
  • HY-W099761
    Sildenafil chlorosulfonyl 139756-22-2 ≥98.0%
    Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor Sildenafil (HY-15025).
    Sildenafil chlorosulfonyl
  • HY-W105700
    Ethylenediaminetetraacetic acid sodium hydrate 10378-23-1 ≥98.0%
    Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.
    Ethylenediaminetetraacetic acid sodium hydrate
  • HY-W140900
    Sodium (S)-3-amino-3-carboxypropanoate hydrate 323194-76-9
    Sodium (S)-3-amino-3-carboxypropanoate hydrate is a biochemical assay reagent, which is utilized in bypass surgery as part of the cardioplegia solution.
    Sodium (S)-3-amino-3-carboxypropanoate hydrate
  • HY-W342283
    Diminazene 536-71-0 98%
    Diminazene is an aromatic diamidine compound primarily utilized for the control of trypanosomiasis, a disease caused by trypanosome parasites. Diminazene primarily binds to the kinetoplast DNA (kDNA) of the trypanosomes, interfering with their replication process. Diminazene also presents avenues for novel pharmacological applications, such as acting as an activator of angiotensin-converting enzyme 2 (ACE2), and showing potential in the treatment of hypertension, rheumatoid arthritis, and as an immunomodulator.
    Diminazene
  • HY-W702027
    Deterenol hydrochloride 23239-36-3 99.74%
    Deterenol hydrochloride (AL842) is a selective beta-agonist. Deterenol hydrochloride causes vasodepressor, anxiety, increasing heart rate, hypotension palpitation and respiratory distress.
    Deterenol hydrochloride
  • HY-W753672
    2'-O-Methyladenosine-d3 1195030-24-0
    2'-O-Methyl Adenosine-d3 is deuterium labeled 2'-O-Methyl Adenosine. 2'-O-Methyl Adenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyl Adenosine exhibits unique hypotensive activities .
    2'-O-Methyladenosine-d3
  • HY-106950S1
    Fosfructose-13C6 tetrasodium hydrate 99.90%
    Fosfructose-13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma.
    Fosfructose-13C6 tetrasodium hydrate
  • HY-109590S3
    Arachidonic acid-13C4 2692624-40-9
    Arachidonic acid-13C4 (Immunocytophyt-13C4) is 13C labeled Arachidonic acid. Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function.
    Arachidonic acid-13C4
  • HY-111372S1
    Finerenone-d5 98%
    Finerenone-d5 (BAY 94-8862-d5) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
    Finerenone-d5
  • HY-113301S2
    Hexacosanoic acid-d3 2692624-17-0 ≥99.0%
    Hexacosanoic acid-d3 is deuterium labeled Hexacosanoic acid. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
    Hexacosanoic acid-d3
  • HY-B0612DS1
    Lercanidipine-d3 hydrochloride 1189954-18-4 98.14%
    Lercanidipine-d3 (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect.
    Lercanidipine-d3 hydrochloride
  • HY-W004284R
    Heptadecanoic acid (Standard) 506-12-7
    Heptadecanoic acid (Standard) is the analytical standard of Heptadecanoic acid. This product is intended for research and analytical applications. Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis[1].
    Heptadecanoic acid (Standard)
  • HY-W010347R
    L-Homocysteine (Standard) 6027-13-0
    L-Homocysteine (Standard) is the analytical standard of L-Homocysteine. This product is intended for research and analytical applications. L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].
    L-Homocysteine (Standard)
  • HY-W014901S
    Bisphenol F-13C6 1410794-06-7 98.32%
    Bisphenol F-13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F-13C6
  • HY-W015061R
    Phenylacetylglycine (Standard) 500-98-1
    Phenylacetylglycine (Standard) is the analytical standard of Phenylacetylglycine. This product is intended for research and analytical applications. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.
    Phenylacetylglycine (Standard)
  • HY-W009749CR
    L-Cystathionine dihydrochloride (Standard) 61125-50-6
    L-Cystathionine dihydrochloride (Standard) is the analytical standard of L-Cystathionine dihydrochloride (HY-W009749C). This product is intended for research and analytical applications. L-Cystathionine dihydrochloride is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine dihydrochloride protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine dihydrochloride plays an important role in cardiovascular protection.
    L-Cystathionine dihydrochloride (Standard)
  • HY-N9528
    Lyciumin A 125708-06-7 ≥99.0%
    Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension.
    Lyciumin A
Cat. No. Product Name / Synonyms Application Reactivity